Joseph Beavo of University of Washington Attends CAMS&PUMC Master Lecture

2017-06-16

On the afternoon of June 7, 2017, Dr. Joseph Beavo, member of American Academy of Sciences, President of American Society for Pharmacology and Experimental Therapeutics (ASPET), and a professor of the University of Washington, was invited to visit CAMS&PUMC and give a lecture titled "Functions of Phosphodiesterase Isozymes Identified by Phosphoproteomic Analyses". President Xuetao Cao presided over the master lecture.




Present Xuetao Cao first of all introduced Professor Joseph Beavo's academic experiences. Professor Beavo was trained in the laboratory of Earl Sutherland, , a renowned American pharmacologist and physiologist professor, who won the Nobel Prize in Physiology or Medicine in 1971 for separating and discovering the physiological role of cyclic adenosine monophosphate (cAMP) in the metabolic process. Since 1977, Professor Beavo have been worked at the University of Washington and set up a laboratory, mainly engaged in biochemical and pharmacological research and teaching on phosphodiesterase. He has published more than 200 SCI papers, served as editorial board members of Journal of Biological Chemistry (JBC), PNAS, Pharmacological Reviews and other world-class magazines. He was thepresident of ASPET. Professor Beavo was elected as a member ofAmericanAcademyof Sciences in 1996.



Professor Beavo, based on the data of the phosphorylated proteome, showed phosphodiesterases’ synergistic regulation of cAMP in MA-10 and T cell lines. Moreover, his team has found that phosphodiesterase acts in a synergistic manner to form different cAMP "functional pools" in cells, and these pools regulate each stage of the cell pathways and ultimately allow the cells to function differently. Those findings and achievements have provided new insights in understanding cell functions and in drug design.

 

(Text: Department of International Cooperation,Institute of Basic Medical Sciences, Photo:NewsCenter)