Nobel Prize Winner Dr. Bruce Beutler


Dr. Bruce Beutler, Director of the Center for the Genetics of Host Defense at the University of Texas South western Medical Center visited Chinese Academy of Medical Sciences on April 9, 2013. Professor Beutler gave a lecture at the auditorium at Dong Dan San Tiao and had a meeting with scientists from the Young Scientist Innovation Alliance of CAMS. The lecture and meeting were hosted by President Xuetao Cao.

Dr. Bruce Beutler was born in a Jewish family in Chicago on December 29th, 1957. He received his secondary school education at Polytechnic School in Pasadena, CA. He majored in biology as an undergraduate at the University of California, San Diego, where he graduated at the age of 18. He earned his M.D. degree from medical school of University of Chicago at the age of 23. After two years of residency at the University of Texas Southwestern Medical Center, he received his postdoctoral training at Rochefeller University.

Dr. Bruce Beutler is best known for his pioneering molecular and genetic studies of inflammation and innate immunity. He was the first one to isolate mouse tumor necrosis factor-alpha (TNF), and to demonstrate the pro-inflammatory role of TNF in inducing endotoxin-induced shock. Starting early with his research on LPS, Dr. Bruce Beutler was able to identify the LPS receptor in innate immune cells using TNF as end-product. Together with Jules A. Hoffmann, he received one-half of the 2011 Nobel Prize in Physiology or Medicine, for “their discoveries concerning the activation of innate immunity”.

Dr. Bruce Beutler shared his experiences about “Analyzing immunity by forward genetics” at the small auditorium. As a speaker of “CAMS & PUMC Master’s Lectures”, Dr. Bruce Beutler’s fascinating speech drew the attention of a large audience including students and faculties from PUMC and other institutions, clinicians from hospitals affiliated to CAMS, other hospitals, as well as young scientists from other colleges. Dr. Bruce Beutler had a meeting with several young scholars and experienced scientists from the Young Scientist Innovation Alliance of CAMS after the lecture. Issues about the application of genetics in immunological analysis were discussed and a preliminary consensus was reached about the potential research cooperation between two institutions.

(Department of International Cooperation)