Tonghui Zhou 

Ph.D 

Academician

Chinese Academy of Sciences

Chairman

Research Instrument Special Committee of Medical Science Committee

Professor Tonghui Zhou, male, of Han nationality, was born in November 1924 in Guilin City, Guangxi. He’s a researcher with the Institute of Materia Medica of CAMS and PUMC and with National Materia Medica and Metabolite Analysis and Research Center, and a doctoral supervisor. He was elected to be academician of CAS in 1991, then served as a member of the standing committee of the Chemistry Department in CAS from 1992 to 1994, and Deputy Director of the Department from 1994 to 1998.

He graduated from the Department of Chemistry in the School of Science, Peking University in 1994 with Bachelor’s Degree. In 1948, he was enrolled into the major of Analytical Chemistry in the Graduate School of the University of Washington in Seattle, and obtained Master’s Degree and Doctor’s Degree in Aug. 1952. He used to serve as assistant professor for analytical chemistry in the Department of Chemistry in the University of Kansas and researcher of analytical chemistry in Burroughs Wellcome Co., specialized in analytical research of herbal medicinal products. He returned to China in Sept. 1955 and worked at the Department of Materia Medica in Central Health Institute of the Ministry of Health (now the Institute of Materia Medica of CAMS and PUMC) successively as associate researcher, researcher and Director of the Analytical Research Lab. He also successively served part time as a member of the Discipline Appraisal Group of Academic Degrees Committee of the State Council, a member of the Discipline Appraisal Group of National Natural Science Foundation of China, a member of the Pharmacopoeia Commission of the Ministry of Health, a member of Drug Evaluation Committee of the Ministry of Health, Chairman of Scientific Research Instrument Special Committee of Medical Science Committee of the Ministry of Health, Vice Chairman of China Association for Instrumental Analysis, Chairman of Chromatography Special Committee of Chinese Chemical Society, Chairman of Beijing Chemical Society, Vice Chairman of Beijing Analytical Test Society, Director of the Academic Committee of Electrochemistry Open Laboratory of the Institute of Applied Chemistry, CAS, part-time professor of Peking University, Editor-in-chief of Chinese Pharmaceutical Sciences (English Version) and Acta Pharmaceutica Sinica, Deputy Editor-in-chief of Chinese Journal of Pharmaceutical Analysis and Chromatography, and editorial board member of Analytical Chemistry, Journal of Instrumental Analysis, Journal of Analytical Science, Water, Air and Soil Pollution and Phytochemical Analysis.

Zhou is devoted to chemical research of pharmaceutical analysis and analytical research of drug metabolite. In the 1960s, he set down two major developing directions for pharmaceutical analysis office: 1) developing approaches of analyzing effective constituents in Chinese herbal medicine; 2) the application of new technique and methods in pharmaceutical analysis. He established methods of modern instrumental analysis and quality control of more than 40 types of active constituents in Chinese herbal medicine and synthetic drugs.

In 1986, Zhou started to get prepared for founding China Doping Control Center and was later appointed to be its director. He led his colleagues to study the drugs forbidden by IOC to find out characteristic metabolites and built up a complete, advanced chromatography of analeptics, mass spectrum database, the gas chromatography of 100 forbidden drugs in five categories, detection and confirmation methods of gas chromatography-mass spectrum and HPLC, thus passing the examination of IOC with success. The Center was approved by IOC in 1989 and made the world’s 20th, Asia’s third and the Third World’s first qualified doping detection lab, which completed doping detection for the 11thAsian Games with success and boosting China to a significant position in the field of doping control. They were highly commended by the State Ministry of Health, the Sports Department of China and Beijing Government.

In the 1990s, Zhou transferred his research focus to drug metabolism. State Scientific and Technological Commission approved the establishment of National Materia Medica and Metabolite Analysis and Research Center in 1994, and Zhou was appointed to be the director. He studied the metabolic status of NBP compounds of physiological activity, hainanensine derivative HHO7A, compound AF-5, alkannin in the herb lithospermum and securinine, an effective constituent of chirality in securinega suffruticosa, in rats and in vitro (rat liver microsomes), thus identifying the metabolites, revealing the laws and paths of their metabolism and providing new scientific evidence for learning about the action mechanism of drugs and developing new drugs.

For dozens of years, Researcher Tonghui Zhou has had more than 100 papers published, having review papers and monographs amounting to over 60. He’s trained 19 graduates and many middle-aged and young technicians and visiting scholars, most of whom have become technical backbones in their units. He edited many monographs and “English-Chinese and Chinese-English Dictionary of Analytical Chemistry” (Edition 1 and Edition 2) he led to edit and Manual of Analytical Chemistry (Edition 2, 1-10 Volumes) are both essential reference books for the major of Analytical Chemistry and have become permanent stores in labs of chemical analysis. In 2004, he was granted the “Famous Author Award” by the Science Press; the Paper Chromatography and Thin-layer Chromatography he edited won the second place in National Excellent Science and Technology Books Selection of the National News Publication Bureau and the third place in Science and Technology Progress Award of the Ministry of Health, and the monograph Modern Research of Chinese Herbal Medicine won the first place in Science and Technology Progress Award of the Ministry of Health.

Professor Zhou was honored with several other awards: in 1989 he was listed among Beijing Outstanding Teachers; in 1990 and 1992 he won Capital Labor Medal; in 1992 he won National Labor Medal; in 1995 he was granted the title of Beijing Outstanding Worker and the Science and Technology Innovation Award of the Ministry of Health; his engagement in doping control won him the first place in National Science and Technology Progress Award and special award in Science and Technology Progress Award of the Sports Department of China.